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Possible food and drug interactions when taking this medication
When you are taking Zyban, it is especially important that your health care professional know if you are taking any of the following:
- Alcohol or
- Antipsychotics (medicine for mental
illness) or
- Corticosteriods(cortisone-like medicine) or
- Fluoxetine (e.g., Prozac) or
- Lithium (e.g., Lithane) or
- Maprotiline (e.g., Ludiomil) or
- Theophylline (e.g., S
omophyllin-T) or
- Trazodone (e.g., Desyrel) or
- Ritonavir (e.g., Norvir)¡XUsing these medicines with Zyban may increase the risk of seizures
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What special precautions should I follow?
A variety of conditions can predispose you to seizures, including:
- Prior head injuries
- Prior seizures
- Central nervous system tumors
- Cirrhosis of the liver
- Too m
uch alcohol
- Abrupt withdrawal from alcohol, tranquilizers, or sedatives
- Addiction to narcotics or cocaine
- Use of over-the-counter stimulants or diet pills
- Use of diabetes m
edications
- Use of antidepressants, major tranquilizers, steroids, or theophylline
If any of these apply to you, use Zyban with care. If you do have a seizure while taking Zyban, stop
taking the drug and never take it again.
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What special precautions should I follow?
Your doctor should check your progress at regular visits, especially during the first few months of treatment with this medicine. The amount of Zyban you take may have to be changed often to meet the
needs of your condition and to help avoid unwanted effects.
Do not take Zyban within 14 days of taking an MAO inhibitor.
Zyban is sold under different brand names for different uses.
If you are already taking medicine for mental depression or to help you stop smoking, discuss this with your health care professional before taking Zyban. It is very important that you receive only o
ne prescription for Zyban at a time.
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Why is this medication prescribed?
Zyban was introduced in the USA in 1985 and was withdrawn in 1986 because of an unacceptable incidence of seizures. In 1989 it was reintroduced in the USA (maximum dose of 450 mg daily). Zyban was fir
st approved in Canada in 1998 as an SR twice-daily formulation. In one RCT buproprion SR, 150 mg daily and 150 mg BID, were similar and more effective than placebo based on physician rated scores of d
epression at 8 weeks.8 In 2 RCTs Zyban (150-400 mg/day) was similar in effectiveness to sertraline (50-200 mg/day) at 8 weeks, but the incidence of satisfaction with sexual functioning was less with s
ertraline (63%) than buproprion (79%) and placebo (78%). 9, 10
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What side effects may occur?
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zyban.
<
br> The most common side effects are:
Dry mouth and sleeplessness
These are generally mild and usually disappear after a few weeks. If you have difficulty sleeping, avoid taking Zyban close t
o bedtime and ask your doctor about reducing your dosage.
More common side effects may include:
Abdominal pain, abnormal dreams, anxiety, constipation, diarrhea, disturbed concentration
, dizziness, joint pain, increased cough, itching, nasal inflammation, nausea, nervousness, rash, sore throat
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Symptoms of overdose may include:
Information on Zyban overdose is limited. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.
Symptoms of Z
yban overdose may include:
- Blurred vision, confusion, grogginess, jitteriness, light-headedness, nausea, seizure, sluggishness, visual hallucinations
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